鼻咽癌發生率與EB病毒檢測的文獻整理

鼻咽癌發生率

台灣約11/每10萬人

中國香港約25/10萬人[1]

家族史的影響

一等親有鼻咽癌, 得到鼻咽癌的風險增加7.6倍[2]

EB病毒檢測

EB EA+NA-1 IgA:

根據2001年刊載在Clinical Otolaryngology的台灣資料[3]

• 單一檢測表現
• Sensitivity: 98.1%
• Specificity: 81.8%

EB VCA IgA:

根據2016年的一篇meta-analysis, pooled sensitivity及specificity如下[4]

• 單一檢測的表現
• Sensitivity:83%(95%CI: 82%-84%) 

• Specificity:88%(95%CI: 87%-89%)

•  並非特別理想，建議合併其他檢測進行判讀

EB DNA:

根據一篇發表在Cancer Research的研究[5]

• 檢測表現
• Sensitivity:96% 
• Specificity:93%

 

 

Reference:

1. Barnes L, Eveson JW, Reichart P, Sidransky D. Pathology and Genetics of Head and Neck Tumours. In: World Health Organization Classification of Tumors, IARC Press, Lyon 2005.
2. Ung A, Chen CJ, Levine PH, Cheng YJ, Brinton LA, Chen IH, Goldstein AM, Hsu MM, Chhabra SK, Chen JY, Apple RJ, Yang CS, Hildesheim A. Familial and sporadic cases of nasopharyngeal carcinoma in Taiwan. Anticancer Res. 1999 Jan-Feb;19(1B):661-5. PMID: 10216473.
3. Hsu MM, Hsu WC, Sheen TS, Kao CL. Specific IgA antibodies to recombinant early and nuclear antigens of Epstein-Barr virus in nasopharyngeal carcinoma. Clin Otolaryngol Allied Sci. 2001 Aug;26(4):334-8. doi: 10.1046/j.1365-2273.2001.00489.x. PMID: 11559349.
4. Chen Y, Xin X, Cui Z, Zheng Y, Guo J, Chen Y, Lin Y, Su G. Diagnostic Value of Serum Epstein-Barr Virus Capsid Antigen-IgA for Nasopharyngeal Carcinoma: a Meta-Analysis Based on 21 Studies. Clin Lab. 2016;62(6):1155-66. doi: 10.7754/clin.lab.2015.151122. PMID: 27468579.
5. Lo, Y. D., Chan, L. Y., Lo, K. W., Leung, S. F., Zhang, J., Chan, A. T., ... & Huang, D. P. (1999). Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer research, 59(6), 1188-1191.